Molecular physiology of pain

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Collection: Hors collection
Publisher: DOIN
Pages: 256
Format: 17 x 24 cm
ISBN : 978-2-7040-1619-8
ISBN élec : 978-2-7040-1619-8
Printed in: French
Publication date: 05/12/2019

For the first time in French language,
the reference book dealing with the neurobiological, physiological and molecular aspects of pain

• Through a popularized approach, this book presents recent scientific data to understand the neurobiology of pain at the body level, physiology and pathophysiology, and at the cellular level, the molecular aspects of the systems involved in the genesis and modulation of pain information. "Pain" because there are several: acute pain due to excessive nociception, chronic inflammatory pain, chronic neuropathic pain, mixed cancer pain, phantom limb pain, idiopathic no-disciplinary pain.

• The objective of this book is to explain the complexity of pain, emphasizing the particular complexity of the transition from acute to chronic pain, the main problem faced by clinicians due to the great difficulty of relieving it.

• The book outlines the main contributions of pain research. This includes introductory themes that allow the reader to grasp pain in its complexity, and others, much more specific, such as cancer pain, pain memory and the molecular aspects of endogenous opioid and cannabinoid systems.

• Few doctors are trained in pain management and it is therefore important to be able to provide a scientific book that allows a better understanding of pain. It will also be very useful for all students wishing to improve their knowledge of the medical studies and the various diplomas associated with the teaching of pain (capacity, DU-DIU) but also scientific studies in neuroscience.

Bernard Calvino
is Honorary Professor of the Universities of Neuroscience, former Professor of Physiology at ESPCI (École Supérieure de Physique et de Chimie Iindustrielles, Paris)



 What is pain?
 Transition from acute to chronic pain - neuroplasticity
 Pain cells
 Experimental models of pain
 Morphine and endogenous opioid systems
 OIH (Opioid Induced Hyperalgesia): a paradoxical phenomenon, opioid-induced hyperalgesia
 Endogenous cannabinoid systems
 Ionic channels and pain: the TRP family and nociceptive thermal sensitivity (I)
 Ionic channels and pain (II)
 Cancer and pain - animal models of pain associated with cancer: neurotoxicity of anti-cancer molecules and bone metastases
 Pain memory: molecular, cellular and systemic memory - from LTP to phantom-limb pain
 Neuromodulation - neurostimulation and pain
 Evolution of the different conceptions of pain in Henri Laborit
Conclusion - Pain and suffering: meaning, meaning, origin of pain