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An educational and illustrated work
connecting biology and clinical medicine.
The nucleus is the control site for all cell signalling. The entire genetic message is done by a large number of molecular tools that reproduce, protect and restore the genome, enabling the transcription of messengers that are translated into proteins responsible for cell function. In normal cells, changes in genome surveillance and repair processes contribute to oncogenesis. On the other hand, cancer cells often present with changes to mechanisms that preserve genetic information.
The many changes to these nuclear events offer many different approaches for targeted therapy. This 7th volume from the collection is dedicated to targets that currently appear to be the most relevant. Each chapter explores one of these targets, showing how an approach to mechanisms, and even to oncogenesis, enables to develop active pharmacological agents to treat cancer.
Interfering with DNA repair defects thanks to PARP1 inhibitors, restoring p53 function in cells where it is not active, blocking cell cycle progress by targeting the cycle’s motor or regulatory kinases, preventing the telomerase from immortalising cell lines, acting on histone control over gene transcription, are some the main approaches open to nuclear targeting.
This book is an essential source of information for understanding the new targeted therapy approaches of cancers.